Sun Exposure - UV radiation from the sun stimulates melanocytes (cells that produce melanin) to produce more melanin, leading to tanning and sunspots. Prolonged or unprotected sun exposure can exacerbate existing hyperpigmentation.
Hormonal Changes - Fluctuations in hormones, such as during pregnancy (melasma or "pregnancy mask"), menopause, or when taking hormonal medications like birth control pills, can trigger increased melanin production in certain areas of the skin.
Inflammation and Injury - Skin inflammation or injury, such as acne, eczema, psoriasis, or even aggressive skin treatments like chemical peels or laser therapies, can lead to post-inflammatory hyperpigmentation (PIH). This occurs when melanocytes are stimulated by inflammation to produce excess melanin.
Genetics - Some individuals are genetically predisposed to developing hyperpigmentation, such as freckles or age spots, due to variations in melanin production or distribution.
Medications - Certain medications, such as antimalarial drugs, antibiotics (like tetracyclines), and chemotherapy drugs, can cause hyperpigmentation as a side effect.
Skin Trauma - Physical trauma to the skin, such as cuts, burns, or abrasions, can trigger melanin production as part of the healing process, leading to darkening of the affected area.
Skin Conditions - Certain skin conditions, like melasma, post-inflammatory hyperpigmentation (PIH), and certain types of dermatitis, can cause patches of darkened skin due to increased melanin production.
Age - As we age, our skin's ability to regulate melanin production may decrease, leading to age spots or "liver spots" on areas frequently exposed to the sun.